Combating Exercise Induced Immune System Suppression With Science In Sport Immune Tablets - Bibrave Product Review

"Disclaimer: I received Science In Sport Immune Tablets to review as part of being a BibRave Pro. Learn more about becoming a BibRave Pro (ambassador), and check out BibRave.com to review, find, and write race reviews!"


I remember the first time I experienced it almost immediately after one of my long training runs preparing for my first marathon in 2009. It was probably a 17 or 18 mile run in some cooler temperatures in late February or early March. Soon after arriving back home, I started sniffling, sneezing, and just suddenly feeling like I was hit with a very sudden and quick onset of a bad cold. In all my years of running I had never experienced this before. However, I was also running a greater volume and the longer distances than I had ever run before. Little did I know how much impact endurance training and workouts can have on the performance of your immune system. In fact, Nieman (2007) reports that exercise induced changes can adversely impact the immune system in multiple ways and may last between 3 and 72 hours. Thankfully for me, my initial experience with exercise induced immune system suppression was nearer the shorter time period of that range and all of my symptoms seemed to disappear as quickly as they presented themselves, just a few hours after I got out of a warm bath.

So what do us runners who enjoy running for prolonged periods do to combat having constantly suppressed immune systems due to our running habits? Nieman (1998) reported that the data from two studies examining carbohydrate ingestion of marathon runners and triathletes suggest that overall physiologic stress is diminished in the groups of athletes that were given a carbohydrate ingestion treatment compared to athletes receiving a placebo treatment based on hormonal and immune responses. The carbohydrate treatment in these studies was consumed in the form of a carbohydrate beverage (think Gatorade or Tailwind) while running or cycling. The data (Figure 2) supports the hypothesis model diagramed in Figure 1 showing that carbohydrate ingestion during prolonged workouts results in high plasma glucose levels and reduced cortisol levels which ultimately helps to counter negative impacts to immune system function (Nieman, 1998).








That’s great to know, but most of us runners are already hydrating during our long runs with some type of carbohydrate beverage. Is there anything post workout that can help lessen the negative impacts of prolonged exercise on the immune system? Step up Science In Sport (SIS) immune tablets, it is your time to shine! These effervescent tablets quickly dissolve in water and are designed to maintain healthy immune system function after intense or prolonged physical efforts. Each SIS immune tablet provides vitamin C (200 mg) and iron (2.5 mg) in addition to key electrolytes that help aid rehydration following exercise. Vitamin C is a highly effective antioxidant that contributes to immune defense in a multitude of ways by supporting cellular functions (Carr and Maggini, 2017). Zinc is an essential trace element that affects the integrity of the immune system in many ways including acting as a cofactor in over 300 enzymes that influence organ functions and have indirect impacts on the immune system (Dardenne, 2002; Rink, 2007).

So the science behind Science in Sport immune tablets checks out, but how did they work for me. I began using SIS immune tablets daily about 3 weeks before my first 24 hour race. I always tend to get nervous about getting sick leading up to a race, so this was the ideal time for me to take any and every precaution to avoid any kind of cold or respiratory issues. The first item to note is the taste. Like all the other SIS products I have tried, the flavor of their immune tablets impressed me compared to workout supplements produced by other brands. I usually find the flavor of most supplements to be overpowering or too sweet. That was not the case with SIS immune tablets. I began looking forward to a tall, cool glass of their light orange flavor during my runs.

But did they work? Did they do what they claim to do?

Well, I didn’t get sick at all leading up to the 24 hour race I was preparing for while using SIS immune tablets daily. Additionally, I didn’t get sick at all following the 24 hour race where I put my body (immune system included) through some pretty serious stress considering the length and intensity of the effort and the sleep deprivation. While I can’t say that my good health was solely the result of using SIS immune tablets, they very well likely played a role and at the very least they gave me the mental comfort of knowing that I was taking additional precautions to protect myself and set myself up as best I could to achieve my goals on race day. So at the end of the day, SIS immune tablets will likely become a standard pre race and post race practice for me.

Literature Cited

Carr, A.C. and S. Maggini. 2017. Vitamin C and Immune Function. Nutrients 9(11): 1211.

Dardennene, M. 2002. Zinc and Immune Function. European Journal of Clinical Nutrition (56): 20-23. 

Nieman, D.C. 1998. Influence of Carbohydrate on the Immune Response to Intensive, Prolonged Exercise. Exercise Immunology Review (4): 64-76.

Nieman, D.C. 2007. Marathon Training and Immune Function. Sports Medicine (37): 412-415. 

Rink, L. 2007. Zinc and the Immune System. Proceedings of the Nutrition Society 541-552.

Adventure Trail Run - 24 Hour Event 2021

My first place overall finisher award!

It’s been about 3 days since the finish of the Adventure Trail Run - 24 Hour Event as I begin this report. Other than some sore toes from a few blisters that developed under my nails and minor muscle aches in my quads and calves, I’m feeling mostly recovered. For a 24 hour effort, the physical recovery seemed pretty quick and not too painful. It’s more the mental recovery that’s a little harder to move past with this race. It’s not that I’m not proud of the effort I put forth or what I did achieve. The truly stinging part of replaying all the scenes in my mind of how those 24 hours were spent is how close I came to nailing my top goal while just falling a little short. I had a very specific goal for this race: to break the course record of 108 miles. My final official mileage was 103.1 when I stopped with about a half hour left on the clock. When it’s that close for a nearly 24 hour effort, the “what if”s and “if only”s seem to breed and multiply in your brain.

The night sky the whining before the race.

The Adventure Trail Run is a timed trail running event held at Prince William Forest Park (National Park Service) in Triangle, VA. This year was the 15th anniversary of the event and they offered 8 hour solo, 4 person relay 24 hour, and solo 24 hour options. While I chose the solo 24 hour because I had never run that race format before and I wanted to test myself with that style of race, the 4 person 24 hour relay option definitely seemed like a fun way to spend a weekend running with friends.

Just before the start!

The course was basically a lollipop design with a 1 mile out and back to a 4 mile loop. The 1 mile out and back section was definitely the most challenging in my opinion. It was probably the most consistently technical section of the course with seemingly endless stretches of jagged rocks and ankle breaking exposed roots. It also had many short but steep climbs and descents to deal with. During the first mile of the race, I immediately thought I’d have to reevaluate my goals as I wasn’t expecting that technical of a course. Thankfully, the 4 mile loop was far more runnable. In addition to the technicality of that entirely narrow single track section was the fact that it was also the section of the course where you had to deal with two way traffic of runners. Since this was a relatively small event (around 100 runners) it didn’t present a major problem, but with 50k and 100k runners on the course at the same time as the 24 hour runners, it did feel a bit congested to me on a few occasions.

My gear for the race.

The 4 mile loop section of the course was a totally different story. Even the more technical sections, climbs, and descents were more runnable than the initial 1 mile out and back. This year the loop was run in a counterclockwise direction. Apparently the race reverses direction of the loop every year. From the start of the loop to the halfway point fluid only aid station was nearly all smooth, buttery, flat single track trails with the exception of a short climb with a couple switchbacks and few technical rocky sections where you had to be careful of your footing. Immediately after the aid station was a short stretch of boardwalk to run on and then the longest sustained climb of the course. The climb followed a stretch of what appeared to be a fire road for about a half mile and up about 150 feet. The rest of the loop was all single track trail with a few technical rooty sections and a few short climbs, but nothing too intense.

My cabin for the night before the race.

I alluded to it earlier about how the race went in my first paragraph, and I’ll expand on that now. I set what may have been a lofty goal for myself: to break the course record of 108 miles. Obviously, I came up a little short with my final official mileage of 103.1. It’s an especially disheartening form of failure when you’re on pace for your goal for so long and come so close to your goal, but it just very slowly becomes more and more apparent over the course of 24 hours of hard effort and battling exhaustion that it is increasingly unlikely of being attained. For the first 50k I was maintaining a pace faster than necessary and building in a bit of a cushion as I was pretty sure I would slow down for the last 12 hours and the early hours of the morning. As the day wore on and fatigue and exhaustion began to build, I checked my overall pace on my watch ever more frequently hoping to stay under that 12:48 pace that I had calculated I needed to hit my goal. I wasn’t exactly sure if or when my pace would roll over that threshold, so I continued to push on in hopes that I could fend off the ever slowing pace that my watch was reporting.

The inside of the cabin.

Initially it was mostly the aid station stops between loops that seemed to be the primary cause of my slowing pace. I’d check my watch going into and leaving and consistently find my pace slowed by about 10 seconds per mile with each pass through. I tried to get through more efficiently, but filling bottles, emptying gel packages, grabbing more gel packages, and eventually eating some real food all takes time. I was great through the 50k mark when all my calories came from gels and hydration, but when I started feeling the need to add some real food for calories my aid station stops tended to take a bit longer. The data shows that my slowest mile (with an aid station stop) up to the 50k mark was 15:55 and my overall average pace was 11:25 per mile.

A temporary tattoo I tried it for the race.

I still felt good and had hopes of hitting my goal even at the 50 mile mark. I was still at an overall pace of 12:31 per mile. I knew it was going to be close and a struggle at that point, but I thought it might still happen. But then around the 100k mark my pace began to suffer a bit more and my aid stops became more damaging to my overall pace. It was right around that point that my overall average pace rolled beyond my goal threshold and jumped to 12:50 per mile. Although this was a disheartening point for me, it didn’t crush me or make me want to quit. Even if I wasn’t going to hit my goal, I still wanted to get as close as possible. I held on to hope that things could still turn around. I was only about 13 hours into a 24 hour race at that point.

Most of my gel packaging.

Unfortunately, things never really turned around. I never got that major energy burst that I hoped for to put me back within reach of my goal. Things never got really bad either. I continued to move steadily and well, just not well enough. With about 8 hours left in the race the race director let me know that second place was only about 40 minutes behind me. That gave me a bit of a boost of motivation to pick up my pace for a couple laps, but it still wasn’t enough for me to get back to my target pace. As the 24 hour clock began to wind down, I finished my last full lap to hit the 100 mile mark with about an hour and 20 minutes left. I knew I wouldn’t complete another full loop, but I could get credit for a half loop if I made it to the midway aid station before the clock ran out. There was no reason not to keep going, so off I went for three more miles. I reached the midway aid station with about a half hour left in the race and called it there.

Preparing for the drive home.

With that half hour left to burn at the end of my race, I immediately began thinking about how many more minutes I would have needed to run the last 3 miles to finish that final lap which would have tied the course record. I thought another 15 would have gotten me damn close; 20 would have pretty much guaranteed it. After looking at my data, those thoughts turned out to be pretty accurate. My average pace for the last 20 miles without aid station stops was just over 15 minutes per mile. An extra 15 minutes may have gotten me back home to tie the course record. But where would that time have come from? I know I could have saved some time during my aid station stops. My 7 slowest miles included an aid station stop and clocked in at an average of 21:05 per mile; there is definitely room for improvement there.

At the finish!

And then that’s where the brain games start getting out of hand. If only I had changed shirts faster. If I had packed a 2 liter of Coke in my cooler instead of wasting time to have a cup filled at the aid station I would have saved a few minutes there. If I had eaten those 2 perogies while walking instead of while standing at the aid station I may have shaved off another 2 minutes. It’s all enough to drive you crazy at some point. It’s also enough to make you question why I can’t just be happy with a first place finish at my first 24 hour race. It’s not that I’m not happy about my performance or the win I managed to get. I’m proud of both of those accomplishments. But I don’t think it would be a healthy reaction to set a goal, not reach it, and then not at least be somewhat disappointed about it. It’s kind of the point of a goal. You set it, you aim for it, you work for it, you struggle to reach it. And after all of that, if you come so close but fall slightly short, you should be disappointed in my opinion regardless of other circumstances such as overall race placement which was irrelevant to my goal anyway. Maybe that’s wrong. Maybe I’m ungrateful. Maybe I set my expectations too high. Whatever it is, this one is taking some time to process completely. Regardless of failing to reach my goal, I am happy with my performance and what it indicates about my fitness level and ability to endure and continue to move forward despite a mentally challenging circumstance. It gave me an indication of what I may be capable of at my next race, Pennsylvania’s first backyard ultra, the Keystone Backyard!

Recovery time.

Scott Snell

April 22, 2021

Allstate Detroit Hot Chocolate 15K Race Report

"Disclaimer: I received a free registration to the Allstate Detroit Hot Chocolate 15K to review as part of being a BibRave Pro. Learn more about becoming a BibRave Pro (ambassador), and check out BibRave.com to review find and write race reviews!"


It’s Virtual! I Got to Run Where and When I Wanted!

I’ll be the first to say it, I miss in real life racing. I miss getting to the starting line with other runners. I miss visiting new places and discovering new areas to run as a result of going to races. I miss the excitement of crowds along a race route and the energy boost they provide. I miss the feeling of an actual finish line and meeting and chatting with other runners there over bananas and bagels. I miss all those things that were a part of in real life races that I took for granted. But COVID, but COVID, but COVID… those two terrible words. At least we still have the option to run events virtually to give us a taste of what we’re missing. And as much as virtual events lack compared to IRL events, they do present their own unique benefits.

Virtual events of course negate the need for travel plans and save all the associated costs making them simpler and more affordable. They are also much easier to work into a busy schedule making them more accessible. Don’t like running in the morning? With a virtual race you don’t have to. You’re busy the day of the event? No problem! Run it the day before or the day after. Or run it a week before as I did with the Allstate Detroit Hot Chocolate 15K because I’ll be busy running a 24 hour race on the day of the event. Lastly, virtual events allow you to choose where you run and what kind of terrain you run on. I was indecisive as to whether I wanted to run on roads or trails for the Allstate Detroit Hot Chocolate 15K so I ended up running both on consecutive days because why not?

It Had Been Awhile Since I Had Tried to Run Fast.

One of my goals was to actually try to race this 15K and run it as fast as possible. Well, I did not follow through with this goal. With a racing goal that has been on my “to do” list falling on the same day as the Allstate Detroit Hot Chocolate 15K I decided to make some adjustments. I have wanted to test myself by running a 24 hour race for the last 3 years or so. I finally registered for a 24 hour race in April last year which was cancelled (COVID) and rescheduled to April 17th 2021, the same date as the Allstate Detroit Hot Chocolate 15K. Thankfully with the Hot Chocolate 15K being virtual I could run it a week in advance. Even so, I did not want to push too hard for it as I wanted to be completely recovered and in top shape for my 24 hour race. Maybe it sounds like an excuse, but I have what may be some lofty goals for the 24 hour race and I don’t want to set myself up for failure or with excuses when things get tough there, which I expect them to at some point.

St. Jude Children’s Research Hospital is the Official Charity Partner.

A major reason why I ran the Allstate Detroit Hot Chocolate 15K was because the race is an official charity partner of St. Jude Children’s Research Hospital. The mission of St. Jude Children’s Hospital is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. I love what they stand for as a nonprofit organization and the fact that no family ever receives a bill from St. Jude for treatment, travel, housing, or food. This was such a motivating factor for me to run this race that after registering I decided to start an additional fundraising campaign through the St. Jude Heroes program to raise funds as I train for and run ultramarathons this year.

The Allstate Detroit Hot Chocolate 15K Delivered on the Chocolate and Swag!

Another reason I decided to run the Allstate Detroit Hot Chocolate 15K was a simple one: the chocolate. My kids are pretty big fans of all things chocolate. I figured I’ll run the race and whatever swag and chocolate goodies I get can be shared with them. We’ll both get some of our favorites; it will be a win win!

And what a win it was! My kids loved the chocolates and the hot chocolate mix! They also got a pretty big kick out of the unique finishers medal that flips open to reveal a storage area for more chocolate. And for me, the zip up hoodie is super comfortable, warm, and fits great!

While I’ll never be able to say that I believe virtual races can adequately replace in real life races, I don’t think they necessarily have to. I believe the two can coexist. For the time being and until we can safely get back to larger in real life races, virtual races will help me to tide my racing appetite and continue to enjoy my obsession with running.


Scott Snell
April 14, 2021

Taper Week and Calling My Shot For My First 24 Hour Race

It is Monday and less than a week out from my first 24 hour race which makes this a taper week. Along with taper week(s) come a few changes, some good and some not so good. The greatest positive in my opinion is just the additional free time that was spent running and training can now be reallocated to other areas. For me this means more family time and being able to help out more with all of the household chores. While I see this as an overall positive, I probably end up wasting a decent amount of that extra time just scrolling on social media. It takes far more discipline for me to put the phone down and do something productive around the house than it does for me to not even pick the phone up when it’s time for a run. 

So, what about the negative aspects of tapering? Well the most obvious is of course less running. I think it’s true of most runners, I know it is for me, but when I don’t get to run I can get grumpy. My wife may even go as far to say that I have a shorter temper when I go for too long without running. Not benefitting from the mental health aspects of running definitely affects my overall mood. During tapering it’s not so bad for me as there is an end date in sight and it is all in preparation to have the best race day possible, so it is a good trade off. Not running due to injury, that’s a completely different situation. 

Which leads to the second negative I’ve noticed more during this taper period than past ones; I’ve found that I’ve become a bit more anxious. Maybe part of this is just build up to race day nerves after not racing in so long and the lack of the relaxation and mental health benefits that come with running, but a decent part of it is due to becoming overly concerned with injury just before race day. In the past week I’ve paid far more attention to every little twinge of pain and ache anywhere on my body. Especially any area where I may have dealt with a previous injury. A little extra tightness in the calf and I’m worried it’s that calf flare up that took me out for almost a whole month of running last year. A sharp pain in the arch of my foot and I’m immediately thinking I’m going to be sidelined with plantar fasciitis. I’ve mostly been able to calm myself and realize I’m overreacting, but talk about unnecessary stress! 

My final long training run before my first 24 race.

And to close this blog post, as the title suggests I have a very specific goal for this race: to run 112.5 miles before the end of the 24 hours. This equates to 18 loops on the 6.25 mile race course and an overall average pace of 12:48 per mile. This distance would also increase my single run distance PR by about 6 miles completing one of my running goals for the year. Since the current course record is 108 miles, maybe my goal is a bit over ambitious or not necessarily within my capabilities. But why not aim for a greater goal rather than a less challenging one that I’m sure I would be capable of reaching? Obtaining painless goals for the sake of completing goals is a meaningless pursuit in my mind. Shooting for the pinnacle of individual success is one of the most motivating aspects of ultrarunning for me and I don’t plan on that mentality changing. 

Scott Snell 

April 12, 2021

Runderwear Festival of Running and Countdown to My First 24 Hour Race

As I begin this blog post we are quickly approaching the weekend of the Runderwear Festival of Running half marathon. Additionally, this Saturday is exactly 2 weeks out from my first 24 hour race! I am so excited and pumped to have an “in real life” race on my schedule and happening so soon.

I hope to use this weekend’s Runderwear Festival of Running virtual half marathon as a portion of my final weekend of training before rolling into taper mode until my 24 hour race. I’m excited to attempt to run a faster half marathon as it feels like it has been so long since I have pushed myself to run hard for any distance longer than up to a mile. Part two of my plan to use this half marathon as part of my final training weekend is to get out for at least a medium distance run the day after on what I expect to be either tired or sore legs. The thinking behind this is of course that at some point during the 24 hour race my legs will be tired so I want to be prepared and mentally ready to continue to move on those tired legs.

My pace goal for the half marathon is to run an average pace of 8:15 per mile. It’s not shooting for the stars or a PR for me, but my training for the last 5 months hasn’t been focused on speed; it’s been focused on building volume and endurance. Additionally, even if I thought a faster pace was within my reach, I don’t want to overextend myself with only 2 weeks to recover before the 24 hour race which has been my top running goal for the last couple years.

Based on my monthly mileage build up, I feel mentally and physically ready to run for 24 hours straight. I have built volume and endurance with this single race in mind. My last long run to prepare for it was 42 miles at what I considered a comfortable pace. Near the end of that run I wanted to test my legs and see what I had left at that point. I ran my forty-first mile in just a little over 7 minutes. This gave me a huge confidence booster for the 24 hour race. Now I just can’t wait to be on that starting line!


Scott Snell
April 2, 2021